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Autism of Incredible in CBD Oil Research The Potential Benefits

xas1017
11.06.2018

Content:

  • Autism of Incredible in CBD Oil Research The Potential Benefits
  • Autism Spectrum Disorder and Cannabidiol: Have We Seen This Movie Before?
  • Guidance for Physicians
  • New Autism research has had a breakthrough when it comes to CBD oil. In this article we outline some of the incredible benefits CBD oil has in. Some reports describe the effects as miraculous or “unbelievable. However, clinical research remains nearly nonexistent. epilepsy population have observed the potential benefit of CBD on behavioral symptoms of ASD. . /story/ news/world//04/25/marijuana-pot-treatment-children-autism-cannabis-oil/ /. There is a lot to learn about CBD oil for autism and we can help! to study the effects of cannabis in children, due to the potential of CBD and autism is needed to continue to validate these incredible anecdotal reports.

    Autism of Incredible in CBD Oil Research The Potential Benefits

    Cardiovascular effects Hair loss Digestive issues like nausea Swelling and water retention Elevated blood sugar levels Breathing difficulties And more Cardiovascular effects Hair loss Digestive issues like nausea Swelling and water retention Elevated blood sugar levels Breathing difficulties And more In many cases, avoiding traditional treatments is not an option.

    One cannabis-derived medication, Sativex , has already been put to the test, with impressive results, including an improvement in pain levels at rest and during movement, and an increased quality in sleep due to lower levels of pain.

    Learn more about CBD and arthritis relief by going deeper into scientific studies and the endocannabinoid system, today. Disorders that are classified as relating to autism are often shrouded in mystery. While some hereditary links seem to exist, other causes — though hotly debated — have been difficult to nail down with any clarity.

    The symptoms range in both type and severity, from one individual to another. More severe forms are often identified in childhood, while others are often masked — or misidentified — as other conditions like anxiety, OCD, or others. Treatments are often prescribed based on symptoms, in addition to behavioral and cognitive therapies, varying based on the individual patient. This range of symptoms and lack of treatment leaves many parents and adults on the spectrum, wondering where to turn, or where to start.

    Current studies, including one carried out by the UC San Diego School of Medicine , are looking into how the endocannabinoid system may be linked to reducing symptoms associated with autism, due to its role in social reward responsivity, neural development, circadian rhythm and anxiety regulation, all of which are often affected by autism. If these links are found, regulation of symptoms may be possible using therapeutic CBD.

    To learn more about the possible connection between the endocannabinoid — and CBD — for autism, start here. Depression and major depression disorders are the most commonly diagnosed mental health disorders in the world. The potential negative effects of depression are great; each year, over 44, American lives are lost to suicide, with depression noted as a common link. For those who seek help, therapy, lifestyle changes and medications are often recommended. Unfortunately, finding a target treatment is often a long process, with periods of worsening depression and other side effects , including:.

    Preclinical and research findings indicate that, by enhancing the signaling of the endocannabinoid system, CBD may be able to reduce activity related to neuroendocrine stress while enhancing serotonergic and noradrenergic transmission, similar to how current anti-depressants function, but without the side effects. Other research indicates that CBD may provide more fast acting benefits , with a shorter time period between consumption and positive effects for those suffering from depression.

    Finding a way to combat the side effects of depression, allowing sufferers to function at their optimal level of performance can be nothing short of positive. To learn more about early research into the link between the endocannabinoid system, CBD and depression, go deeper, today.

    Sufferers are often faced with fatigue, memory problems, mood changes, and much more. Unlike other chronic conditions, fibromyalgia is not known to cause muscle or joint damage, but the symptoms it causes are no less devastating. Because the cause of fibromyalgia cannot be pinpointed, treatments are often prescribed to lessen the side effects, providing a better quality of life for those who are afflicted with the disease.

    In many cases, as patients become acclimated to specific doses, they are increased, leading to a higher potential for negative effects. Because of its role in treating chronic pain, depression, nausea and appetite issues and even nerve pain, CBD may provide benefits to fibromyalgia sufferers as well. One study, in , found that CBD may be more effective at treating neuropathic pain than opioids.

    A review , demonstrated similar findings. Because the endocannabinoid system may help regulate the way various neurons fire, this is promising for fibromyalgia patients looking for a better way to treat symptoms.

    Correct dosages and ways to administer. Keep up with new studies, trends, products, and deals with CBD Central's cannabidiol newsletter. You can unsubscribe from CBD Central email messages at any time. Could CBD oil provide benefits that traditional medication often fails to offer?

    CBD stands for cannabidiol, a type of cannabinoid. These negative effects include: Liver Damage Cardiovascular Damage Addiction. This is promising news for the majority of aforementioned smokers who want to quit the habit. Have you been diagnosed with epilepsy? Has a loved one? Learn more about CBD and epilepsy , today. Phobias Obsessive Compulsive Disorder And others. One of these might just be CBD. Unlike Type 2 Diabetes, often correlated with lifestyle factors and choices, including weight management, diet and exercise, Type 1 Diabetes is an inherent condition that sufferers have little control over contracting.

    Whether the side effect of a disease — certain cancers, intestinal and digestive system disorders, cystic fibrosis, or others — or, the side effect of the treatment for a disease — medications, chemotherapy, epilepsy drugs, and more — nausea and a loss of appetite can be just as damaging as the disease itself. The science is promising! Recently, this has started to change. Reduce the risk of death following a cardiac event or heart attack for past users.

    Reduce the risk of additional heart attacks after the first in surviving patients. Reduce imminent death-rates among heart failure patients. Reduce cell-death relating to diabetic cardiomyopathy, and more.

    CBD is also helpful in combating and treating conditions that are risk factors for cardiovascular disease, including: Diabetes Stress Anxiety Smoking And more. To learn more about the science behind CBD and the cardiovascular system, or, about its effects on particular conditions, go deeper. Sleep disorders come in many shapes and sizes, but, one thing remains clear: In the medical field, sleep deprivation among practitioners may be responsible for up to , deaths in the United States Sleep.

    Traditional medications for helping an individual sleep have major side effects , including: Dependency with worsening symptoms after medications are discontinued Dizziness A loss of balance Addiction and Withdrawal difficulties.

    Digestive issues Impairment upon waking Shaking Changes in appetite And more. Dependency with worsening symptoms after medications are discontinued Dizziness A loss of balance Addiction and Withdrawal difficulties Digestive issues Impairment upon waking Shaking Changes in appetite And more. While many sufferers of insomnia depend on CBD, due to its natural qualities and low rate of side effects, early scientific studies have begun to explain why. The opioid crisis — the drug category responsible for the most addictions in the United States — is very real.

    Opioids were responsible for over 42, deaths in , rising over 5 times from just a decade earlier, and over 20 percent from alone. Today, over individuals die from overdoses each week in the US. Low energy Headaches Body twitching and shaking Digestive symptoms Muscle pain and body aches. Hot and cold sweats Irritability Anxiety Insomnia And more.

    How could CBD make a difference? Abdominal pain Cramping Gas. Diarrhea Constipation And other unpleasant effects. Because each individual reacts differently to each medication, finding an appropriate protocol can be a challenge, associated with many negative symptoms, including: Researchers have begun to search for a better way. Arthritis hits close to home for many individuals. As a conservative estimate, around 54 million American adults, and , children suffer from arthritis that has been diagnosed by a medical provider, with many more believed to suffer in silence.

    Cardiovascular effects Hair loss Digestive issues like nausea Swelling and water retention. Elevated blood sugar levels Breathing difficulties And more. Cardiovascular effects Hair loss Digestive issues like nausea Swelling and water retention Elevated blood sugar levels Breathing difficulties And more. In many cases, avoiding traditional treatments is not an option.

    In an Israeli study of 74 patients were treated with an oil containing a Study limitations included a lack of control group, reliance on parental report for seizure activity a short duration of the study and lack of measurement of other drug levels. In May , a double-blind, placebo-controlled trial by Devinsky et al was published in the New England Journal of Medicine.

    In March , a randomized, double-blind, placebo-controlled trial was conducted at 24 clinical sites with participants in the United States, the Netherlands, and Poland. This study reported a reduction in monthly drop seizures of Reported side effects were minor and similar to previously described studies.

    An ongoing open-label extension of this trial aims to understand the dose-response effect as well as the long-term efficacy of this therapy. This approval was specifically for the treatment of Lennox-Gastaut syndrome and Dravet syndrome, which are both severe forms of epilepsy that are often resistant to normal epilepsy medicine. The preclinical evidence strongly supports CBD as a potential treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder PTSD.

    This has been limited to acute administration rather than long-term use. Few human studies have yet investigated chronic CBD dosing and more research is needed in this area. A study using rats indicated that cannabidiol could disrupt the consolidation of specific and generalized fear memories. This study may help researchers understand the mechanism behind the effects in the endocannabinoid system, and may hold promise for sufferers of PTSD and other anxiety-related disorders.

    There is early evidence that cannabinoids have potential for treating autism or autism spectrum disorder ASD , a neurodevelopmental disorder that develops in infancy or childhood. The main symptom of ASD is impaired social interaction. Early signs can include unresponsiveness to people, avoiding eye contact or failure to respond to their own names.

    Researchers have found a potential link between autism and the cannabinoid 2 CB 2 receptors in the brain. Pennsylvania and Minnesota are the only states as of July to have approved medical cannabis treatments for autism.

    Research and evidence are still limited on this condition, with no large-scale clinical study results available and only single case study reports and animal research published to date. Schizophrenia is characterized by deficits in learning, memory, attention and executive functioning, and it can severely impact daily living.

    Antipsychotic drugs have limited benefits and thus novel treatments are being investigated. CBD has anti-inflammatory and antipsychotic-like properties, so may hold promise for schizophrenia. This indicates a need for further research prior to implementing treatments at this time. Cannabidiol is thought to modulate various neuronal circuits involved in drug addiction.

    Much of the work in this area has been done on pre-clinical or animal models, with limited human studies to evaluate. In animal studies, CBD was found to have an impact on the intoxication and relapse phase of opioid addiction.

    Data on its effect during the withdrawal phase remain conflicting and vary based on co-administration of other cannabinoids such as THC.

    This is a separate issue than whether cannabis is specifically therapeutic in autism, but the two issues are often conflated. Indeed, plowing through the list and looking up key papers was a tediously predictable endeavor. These finding have in part prompted researchers to apply to conduct research with nonhuman primates in order to further elucidate this link Malcher-Lopes Endocannabinoid system deficiencies are suggested to be involved in the pathophysiology of a growing number of diseases Marco , Russo Pacher and Pertwee both cover the endocannabinoid system in detail Pacher , Pertwee The number of functions that endocannabinoid signaling regulate in the human body is extensive and beyond the scope of this paper Pertwee For sake of brevity only a few potentially relevant aspects will be listed:.

    So what are these elements? Basically, Stone and Bogner cite a whole bunch of papers supporting the conclusions that endocannabinoids:. So, yes, cannabinoids are important molecules in the CNS and elsewhere. No one argues against that. A decent overview of this research suitable for a lay person can be found here , and the original paper is here. This is very preclinical evidence, meaning that it might or might not turn out to be relevant to human ASDs.

    At best, it justifies further study. Many advocates cite scientific literature regarding benefits of cannabis for the treatment of pediatric behavioral conditions, but often, data cited are from animal model-based research that does not yet have translation to human subjects. For example, a study 80 from Stanford University showed that mice with a specific and rare gene mutation linked to autism showed altered endocannabinoid signaling in the central nervous system. These data were then cited by online and print media supporters of medical marijuana e.

    As another example, when another recent study 72 based on a mouse model of Fragile X syndrome described earlier in this review showed alterations in endocannabinoid signaling pathways, these data were referenced in this case, by more mainstream media outlets, such as the Huffington Post 8 and Fox News 82 as evidence for a promising role for cannabis as treatment. Although these and other high-impact studies share important insights into the pathogenesis of autism spectrum disorders ASD and Fragile X syndrome, based on their results alone, it is erroneous and potentially harmful to conclude that cannabis should be used as treatment for either of these disorders at this time.

    Much of the rest of their article boils down to the list I enumerated above plus other correlations, their arguments reduced to, in essence, this:. There might be a direct role for these correlations in causing autism, and some of the signaling pathways might even represent promising targets, including the endocannabinoid pathway or a subset of it. Stone and Bogner go wrong by assuming all of these studies indicate a critical role for endocannabinoids in autism, such as elevated cytokine levels.

    For instance, take a look at this list of effects of cannabidiol CBD:. Whenever writing a research paper that is basic science that could potentially be translated into a treatment for a disease, it is generally considered mandatory to speculate at the end just how this could come about.

    For instance, when scientists write about cannabinoids in the context of models of neurodevelopmental disorders, after all the basic science, cell culture, and animal model work, naturally they try to describe how their results could be pursued so that they translate into a clinical treatment.

    Stone and Bogner quote several of these sorts of speculative statements in the discussion or introduction of papers as though they were Gospel truth, then conclude:. Given the known role of the endocannabinoid system in ASD it seems entirely possible, if not likely, that cannabinoid rich botanical extracts from cannabis can be utilized as useful agents targeting the pathophysiology of ASD, as well as the many debilitating symptoms and conditions associated with it.

    The wealth of options that cannabis has to offer those that suffer from ASD in MI is not currently legally permitted. We believe that needs to change. What all these 75 references really mean is that there is some correlative evidence that the endocannabinoid system is abnormal in autism. Yes, because the law states two doctors have to sign off for use of medical marijuana in children, parents will have to find two doctors, but, really, does anyone think that will be very difficult?

    To recommend a treatment for general use, we need high quality clinical evidence. Is there any such evidence for cannabis oil for autism? The answer is a resounding and unequivocal no. Indeed, an excellent indication of the paucity of evidence regarding cannabis oil and autism is the way Stone and Bogner dance around the issue by citing anecdotal reports about the use of cannabis oil and cannabinoids to treat epilepsy:.

    How can combinations of cannabinoids be put into practical use by individual families? I think this is a good comparison due to the range and complexity of both conditions. CBD continues to prove its effectiveness in treating many types of epilepsy, but not all Porter Anecdotal reports provided in online groups with families that share dosing and other related information to cannabinoid based pediatric epilepsy treatments reveal that in many cases parents and physicians find that an increased ratio of THC is required to increase the efficacy of treatment.

    The range seems to vary significantly from Due to the range of ASD it seems possible that, similar to cannabinoid based epilepsy treatments, varying ratios of cannabinoids specifically CBD: THC will prove to have a greater efficacy overall when compared to individual cannabinoid based treatments like Dronobinal.

    This concept has been further supported by the research and clinical use of Sativex, a 1: THC botanical extract marketed for use in a range of treatments throughout the world Hazekamp , Russo The ability to specifically tailor cannabinoid ratios in botanical extracts from cannabis in a case specific manner may prove an even greater efficacy.

    This is nothing more than handwaving, comparing two different conditions and assuming that what is observed in one condition will apply to another condition. Indeed, as the aforementioned review by Hadland et al. Regarding human data on use of cannabis for developmental and behavioral conditions, to the best of our knowledge, the only available data are from small case series or single studies. For example, one 6-year-old boy with autism was treated with daily dronabinol for 6 months and was noted to have improvement in hyperactivity, irritability, lethargy, stereotyped behaviors, and speech, as measured by the Aberrant Behavior Checklist.

    Another small case series 86 showed an improvement in self-injurious behaviors among adolescents after dronabinol therapy, but to date, the study has not been published, leaving protocol details scarce.

    Autism Spectrum Disorder and Cannabidiol: Have We Seen This Movie Before?

    Check out the studies conducted to see if CBD for autism is a viable are incredibly powerful and carry a long list of side-effects, potential for. Unfortunately, there is no cure for autism, but CBD has recently provided by parents of children with autism who discuss the benefits of CBD, given the potential for brain damage and death from uncontrolled seizures. Collection by Bobbijo Genovese/Autism Mom Cannabidiol benefits for Pain, Mental Illness & Anxiety Check out these 12 incredible ways CBD oil can help! CBD Oil and Autism – More Studies on Cannabidiol .. If it were possible to experience a substantial reduction in the physical and emotional symptoms with a.

    Guidance for Physicians



    Comments

    dramchik1

    Check out the studies conducted to see if CBD for autism is a viable are incredibly powerful and carry a long list of side-effects, potential for.

    daren36

    Unfortunately, there is no cure for autism, but CBD has recently provided by parents of children with autism who discuss the benefits of CBD, given the potential for brain damage and death from uncontrolled seizures.

    soldierdante

    Collection by Bobbijo Genovese/Autism Mom Cannabidiol benefits for Pain, Mental Illness & Anxiety Check out these 12 incredible ways CBD oil can help! CBD Oil and Autism – More Studies on Cannabidiol .. If it were possible to experience a substantial reduction in the physical and emotional symptoms with a.

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